アトロリシンC

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アトロリシンC
識別子
EC番号	3.4.24.42
CAS登録番号	158886-17-0
データベース
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB構造	RCSB PDB PDBj PDBe PDBsum
検索
PMC	articles
PubMed	articles
NCBI	proteins
	テンプレートを表示

アトロリシンC(Atrolysin C、EC 3.4.24.42)は、酵素である^[1]^[2]^[3]^[4]^[5]^[6]。この酵素は、インスリンB鎖のHis⁵-Leu、His¹⁰-Leu、Ala¹⁴-Leu、Tyr¹⁶-Leu、Gly²³-Phe結合を切断する反応を触媒する。これは、アトロリシンBと同じ切断パターンである。また小さな基質では、P2'位の疎水性残基やP1位のアラニン、グリシン等の小さな残基を選択的に切断する。

このエンドペプチダーゼは、ニシダイヤガラガラヘビの毒に含まれる。

出典

^ Bjarnason, J.B. and Tu, A.T. (1978). “Hemorrhagic toxins from western diamondback rattlesnake (Crotalus atrox) venom: isolation and characterization of five toxins and the role of zinc in hemorrhagic toxin e”. Biochemistry 17: 3395–3404. PMID 210790.
^ Fox, J.W., Campbell, R., Beggerly, L. and Bjarnason, J.B. (1986). “Substrate specificities and inhibition of two hemorrhagic zinc proteases Ht-c and Ht-d from Crotalus atrox venom”. Eur. J. Biochem. 156: 65–72. PMID 3514216.
^ Bjarnason, J.B. and Fox, J.W. (1987). “Characterization of two hemorrhagic zinc proteinases, toxin c and toxin d, from western diamondback rattlesnake (Crotalus atrox) venom”. Biochim. Biophys. Acta 911: 356–363. PMID 3101740.
^ Mori, N., Nikai, T., Sugihara, H. and Tu, A.T. (1987). “Biochemical characterization of hemorrhagic toxins with fibrinogenase activity isolated from Crotalus ruber ruber venom”. Arch. Biochem. Biophys. 253: 108–121. PMID 2949699.
^ Shannon, J.D., Baramova, E.N., Bjarnason, J.B. and Fox, F.W. (1989). “Amino acid sequence of a Crotalus atrox venom metalloproteinase which cleaves type IV collagen and gelatin”. J. Biol. Chem. 264: 11575–11583. PMID 2745407.
^ Takeya, H., Onikura, A., Nikai, T., Sugihara, H. and Iwanaga, S. Primary structure of a hemorrhagic metalloproteinase, HT- (1990). “2, isolated from the venom of Crotalus ruber ruber”. J. Biochem. (Tokyo) 108: 711–719. PMID 2081731.

外部リンク

Atrolysin C - MeSH・アメリカ国立医学図書館・生命科学用語シソーラス（英語）

[1] Bjarnason, J.B. and Tu, A.T. (1978). “Hemorrhagic toxins from western diamondback rattlesnake (Crotalus atrox) venom: isolation and characterization of five toxins and the role of zinc in hemorrhagic toxin e”. Biochemistry 17: 3395–3404. PMID 210790.

[2] Fox, J.W., Campbell, R., Beggerly, L. and Bjarnason, J.B. (1986). “Substrate specificities and inhibition of two hemorrhagic zinc proteases Ht-c and Ht-d from Crotalus atrox venom”. Eur. J. Biochem. 156: 65–72. PMID 3514216.

[3] Bjarnason, J.B. and Fox, J.W. (1987). “Characterization of two hemorrhagic zinc proteinases, toxin c and toxin d, from western diamondback rattlesnake (Crotalus atrox) venom”. Biochim. Biophys. Acta 911: 356–363. PMID 3101740.

[4] Mori, N., Nikai, T., Sugihara, H. and Tu, A.T. (1987). “Biochemical characterization of hemorrhagic toxins with fibrinogenase activity isolated from Crotalus ruber ruber venom”. Arch. Biochem. Biophys. 253: 108–121. PMID 2949699.

[5] Shannon, J.D., Baramova, E.N., Bjarnason, J.B. and Fox, F.W. (1989). “Amino acid sequence of a Crotalus atrox venom metalloproteinase which cleaves type IV collagen and gelatin”. J. Biol. Chem. 264: 11575–11583. PMID 2745407.

[6] Takeya, H., Onikura, A., Nikai, T., Sugihara, H. and Iwanaga, S. Primary structure of a hemorrhagic metalloproteinase, HT- (1990). “2, isolated from the venom of Crotalus ruber ruber”. J. Biochem. (Tokyo) 108: 711–719. PMID 2081731.

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