リボヌクレアーゼZ

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リボヌクレアーゼZ
識別子
EC番号	3.1.26.11
CAS登録番号	98148-84-6
データベース
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB構造	RCSB PDB PDBj PDBe PDBsum
検索
PMC	articles
PubMed	articles
NCBI	proteins
	テンプレートを表示

リボヌクレアーゼZ(Ribonuclease Z、EC 3.1.26.11)は、以下の化学反応を触媒する酵素である^[1]^[2]^[3]^[4]^[5]^[6]^[7]。

リボ核酸をエンド型で切断する。転移RNA前駆体の3'末端についた余計なヌクレオチドを除去し、3'末端を生成する。3'-ヒドロキシ基は転移RNAの末端に残り、5'-ホスホリル基は後ろの分子に残る。

この酵素は、補因子を必要としない。

出典

^ Schiffer, S., Rösch, S. and Marchfelder, A. (2002). “Assigning a function to a conserved group of proteins: the tRNA 3′-processing enzymes”. EMBO J. 21 (11): 2769–2777. doi:10.1093/emboj/21.11.2769. PMC 126033. PMID 12032089.
^ Mayer, M., Schiffer, S. and Marchfelder, A. (2000). “tRNA 3′ processing in plants: nuclear and mitochondrial activities differ”. Biochemistry 39 (8): 2096–2105. doi:10.1021/bi992253e. PMID 10684660.
^ Schiffer, S., Helm, M., Theobald-Dietrich, A., Giege, R. and Marchfelder, A. (2001). “The plant tRNA 3′ processing enzyme has a broad substrate spectrum”. Biochemistry 40 (28): 8264–8272. doi:10.1021/bi0101953. PMID 11444972.
^ Kunzmann, A., Brennicke, A. and Marchfelder, A. (1998). “5′ end maturation and RNA editing have to precede tRNA 3′ processing in plant mitochondria”. Proc. Natl. Acad. Sci. USA 95 (1): 108–113. doi:10.1073/pnas.95.1.108. PMC 18142. PMID 9419337.
^ Mörl, M. and Marchfelder, A. (2001). “The final cut. The importance of tRNA 3′-processing”. EMBO Rep. 2 (1): 17–20. doi:10.1093/embo-reports/kve006. PMC 1083803. PMID 11252717.
^ Minagawa, A., Takaku, H., Takagi, M. and Nashimoto, M. (2004). “A novel endonucleolytic mechanism to generate the CCA 3′ termini of tRNA molecules in Thermotoga maritima”. J. Biol. Chem. 279 (15): 15688–15697. doi:10.1074/jbc.M313951200. PMID 14749326.
^ Takaku, H., Minagawa, A., Takagi, M. and Nashimoto, M. (2003). “A candidate prostate cancer susceptibility gene encodes tRNA 3′ processing endoribonuclease”. Nucleic Acids Res. 31 (9): 2272–2278. doi:10.1093/nar/gkg337. PMC 154223. PMID 12711671.

外部リンク

[1] Schiffer, S., Rösch, S. and Marchfelder, A. (2002). “Assigning a function to a conserved group of proteins: the tRNA 3′-processing enzymes”. EMBO J. 21 (11): 2769–2777. doi:10.1093/emboj/21.11.2769. PMC 126033. PMID 12032089.

[2] Mayer, M., Schiffer, S. and Marchfelder, A. (2000). “tRNA 3′ processing in plants: nuclear and mitochondrial activities differ”. Biochemistry 39 (8): 2096–2105. doi:10.1021/bi992253e. PMID 10684660.

[3] Schiffer, S., Helm, M., Theobald-Dietrich, A., Giege, R. and Marchfelder, A. (2001). “The plant tRNA 3′ processing enzyme has a broad substrate spectrum”. Biochemistry 40 (28): 8264–8272. doi:10.1021/bi0101953. PMID 11444972.

[4] Kunzmann, A., Brennicke, A. and Marchfelder, A. (1998). “5′ end maturation and RNA editing have to precede tRNA 3′ processing in plant mitochondria”. Proc. Natl. Acad. Sci. USA 95 (1): 108–113. doi:10.1073/pnas.95.1.108. PMC 18142. PMID 9419337.

[5] Mörl, M. and Marchfelder, A. (2001). “The final cut. The importance of tRNA 3′-processing”. EMBO Rep. 2 (1): 17–20. doi:10.1093/embo-reports/kve006. PMC 1083803. PMID 11252717.

[6] Minagawa, A., Takaku, H., Takagi, M. and Nashimoto, M. (2004). “A novel endonucleolytic mechanism to generate the CCA 3′ termini of tRNA molecules in Thermotoga maritima”. J. Biol. Chem. 279 (15): 15688–15697. doi:10.1074/jbc.M313951200. PMID 14749326.

[7] Takaku, H., Minagawa, A., Takagi, M. and Nashimoto, M. (2003). “A candidate prostate cancer susceptibility gene encodes tRNA 3′ processing endoribonuclease”. Nucleic Acids Res. 31 (9): 2272–2278. doi:10.1093/nar/gkg337. PMC 154223. PMID 12711671.

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